Our mission

Can we predict pathways and outcomes of future evolutionary processes? We work on this question in fast-evolving systems: microbial populations in the laboratory and in clinical environments, viruses and immune repertoires, and cancer cell populations.

We build high-throughput experiments and models to predict the evolution of drug resistance and immune escape, and of the immune responses in their hosts.

We exploit predictions for interventions: antibiotic treatments, vaccines for influenza and coronavirus, and therapies for HIV and cancer that preempt or curb escape evolution.

The Collaborative Research Center is funded by Deutsche Forschungsgemeinschaft (DFG) and was established in January 2018.

Upcoming events

Cologne Evolution Colloqium 08.07.26 | 17:00 Roderich Römhild, IST Austria Genome-wide effects of transposable elements in bacteria [pdf]
Delbrück Lecture 15.07.26 | 17:00 Victor Greiff, University of Oslo Prediction of adaptive immunity using systems immunology [pdf]
CMMC Symposium 28-30 Sep 2026 University of Cologne Metabolic Control of Tissue Regeneration and Degeneration [pdf] [website]
Workshop and Symposium 28-30 Sep 2026 Yale University Physics and Computation in Immunology [pdf] [website]

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Science news

February 2026

Prestigious Marie Curie Postdoctoral Fellowship awarded to Dr. Gabriela Petrungaro. Congratulations Gabi!

February 2026

Research Fellowship at the Flatiron Institute, New York awared to Dr. Roberto Morán-Tovar. Congratulations Roberto!

November 2025

The CRC 1310 has been extended for four years!
[press release]